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The 12 Best Serums for Skin Over 50

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Serums are essential to skin health—as a bonus, they also afford one of the most sensorial moments of a skin-care routine. The serums you used in your 20s, likely for hydration or dialed-up dewiness, may not necessarily be the best serums for you in your 50s. There are many serums that target signs of aging, from wrinkles to moisture loss, that are perfectly formulated to help rejuvenate skin. We’ve curated a list of the best serums for skin over 50.

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Clinique Smart Clinical Repair Wrinkle Correcting Serum ($99)

This serum is part of Clinique’s most advanced anti-aging line. Scientists and dermatologists helped design the formula, which features peptides, retinoids and hyaluronic acid. Clinique studies found the serum to be as effective as one laser treatment on the look of lines and wrinkles after 16 weeks—need we say more?

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SkinCeuticals CE Ferulic ($169)

This cult-classic standby is great for many things, from brightening skin to protecting against environmental aggressors. However, its most beloved benefits include improving signs of aging like fine lines, wrinkles and laxity.

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True Botanicals Chebula Active Serum ($90)

Among the top-performing anti-aging serums at a fraction of the price, this True Botanicals product is a keeper, and an Olivia Wilde favorite. If you want softer, smoother skin and a reduced appearance of wrinkles in just weeks, grab this bottle.

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Maya Chia The Super Lift Vitamin C-More Treatment ($110)

For both a quick fix and long-term benefits, Maya Chia’s serum is a great investment. Packed with vitamin C, tranexamic acid, ferulic acid esters, niacinamide, peptides and stem cells, this formula has the ability to brighten skin while also reducing signs of aging.

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Valmont V-Line Lifting Concentrate ($290)

This anti-wrinkle and fine line serum does it all. It protects skin from free radicals, tightens and regenerates tissue and reduces wrinkles in the long-term for an all-around more youthful appearance.

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OBAGI Medical ELASTIderm Facial Serum ($198)

The unique Bi-Mineral Contour Complex in this formula helps support skin elasticity to help it bounce back from signs of aging more easily. Skin soaks up this fast-acting serum leaving you feeling better just moments after application.

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La Prairie Skin Caviar Liquid Lift ($750)

This potent firming serum provides both an immediate lifting sensation and a more lifted appearance over time with continued use. It enhances skin’s firmness, elasticity and volume by helping to restore skin density. You’ll also notice fine lines and wrinkles are visibly reduced after use.

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Dieux Skin Deliverance ($69)

A perfect soothing serum for those with aging skin that’s also dry and irritated. Utilizing cannabinoids, niacinamide and other calming ingredients, this formula will even out tone, smooth skin and reduce irritation.

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Eminence Firm Skin Acai Booster-Serum ($64)

Superfruit acai is not only good for your body, but it’s also great for your skin. Reviewers note fast and noticeable changes in their skin after using this serum, including reduced signs of aging and smoother, more hydrated, plumper, revitalized skin.

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Epionce Intense Defense Anti-Aging and Repair Serum ($150)

Unique ingredients like Spanish needle, melon fruit extract, shiitake mushroom and flax extract give this serum an edge. It goes to work on signs of aging while also helping repair the skin barrier.

Award Photo: Intense Defense Serum
Award Photo: Intense Defense Serum